COTC
COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus. COTC inhibits glyoxalase in the presence of glutathione (GSH). COTC also inhibits the proliferation of HeLa cells (IC50 = 18 ug/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model[1].