Publications
Human Amyloid Beta Antibodies
Key References
Jensen M, Hartmann T, Engvall B, Wang R, Uljon SN, Sennvik K, Naslund J, Muehlhauser F, Nordstedt C, Beyreuther K, Lannfelt L.
Quantification of Alzheimer Amyloid β Peptides Ending at residues 40 and 42 by Novel ELISA Systems
Mol Med. 2000 Apr;6(4):291-302 PubMed
Ida N, Hartmann T, Pantel J, Schroder J, Zerfass R, Forstl H, Sandbrink R, Masters CL, Beyreuther K
Analysis of Heterogenous βA4 Peptides in Human Cerebrospinal Fluid and blood by a Newly Developed Sensitive Western Blot Assay
J Biol Chem. 1996 Sep 13;271(37):22908-14 PubMed
Other References
Melov S, Adlard PA, Morten K, Johnson F, Golden TR, Hinerfeld D, Schilling B, Mavros C, Masters CL, Volitakis I, Li QX, Laughton K, Hubbards A, Cherny RA, Gibson B, Bush AI.
Mitochondrial oxidative stress causes hyperphosphorylation of Tau.
PLoS ONE 2007; 2(6): e536 PubMed
Serneels L, Dejaegere T, Craessaerts K, Horre K, Jorissen E, Tousseyn T, Hebert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B.
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo.
Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1719-24. Epub 2005 Jan 21. PubMed
Rufenacht P, Guntert A, Bohrmann B, Ducret A, Dobeli H.
Quantification of the A beta peptide in Alzheimer’s plaques by laser dissection microscopy combined with mass spectrometry.
J Mass Spectrom. 2005 Feb;40(2):193-201. PubMed
Lefranc-Jullien S, Lisowski V, Hernandez JF, Martinez J, Checler F.
Design and characterization of a new cell-permeant inhibitor of the beta-secretase BACE1.
Br J Pharmacol. 2005 Mar 7; [Epub ahead of print] PubMed
Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Muller-Spahn F, Haass C, Czech C, Pradier L, Muller WE, Eckert A.
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis.
J Biol Chem. 2004 Nov 26;279(48):50310-20. Epub 2004 Sep 14. PubMed
Pitsi D, Octave JN.
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.
J Biol Chem. 2004 Jun 11;279(24):25333-8. Epub 2004 Apr 15. PubMed
Casas C, Sergeant N, Itier JM, Blanchard V, Wirths O, van der Kolk N, Vingtdeux V, van de Steeg E, Ret G, Canton T, Drobecq H, Clark A, Bonici B, Delacourte A, Benavides J, Schmitz C, Tremp G, Bayer TA, Benoit P, Pradier L.
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model.
Am J Pathol. 2004 Oct;165(4):1289-300. PubMed
Ciccotosto GD, Tew D, Curtain CC, Smith D, Carrington D, Masters CL, Bush AI, Cherny RA, Cappai R, Barnham KJ.
Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution.
J Biol Chem. 2004 Oct 8;279(41):42528-34. Epub 2004 Jul 28. PubMed
Dolev I, Michaelson DM.
A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade.
Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13909-14. Epub 2004 Sep 13. PubMed
Fassbender K, Walter S, Kuhl S, Landmann R, Ishii K, Bertsch T, Stalder AK, Muehlhauser F, Liu Y, Ulmer AJ, Rivest S, Lentschat A, Gulbins E, Jucker M, Staufenbiel M, Brechtel K, Walter J, Multhaup G, Penke B, Adachi Y, Hartmann T, Beyreuther K.
The LPS receptor (CD14) links innate immunity with Alzheimer’s disease.
FASEB J. 2004 Jan;18(1):203-5. Epub 2003 Nov 3. PubMed
Grimm HS, Beher D, Lichtenthaler SF, Shearman MS, Beyreuther K, Hartmann T.
gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.
J Biol Chem. 2003 Apr 11;278(15):13077-85. Epub 2003 Jan 29. PubMed
Barnham KJ, Ciccotosto GD, Tickler AK, Ali FE, Smith DG, Williamson NA, Lam YH, Carrington D, Tew D, Kocak G, Volitakis I, Separovic F, Barrow CJ, Wade JD, Masters CL, Cherny RA, Curtain CC, Bush AI, Cappai R.
Neurotoxic, redox-competent Alzheimer’s beta-amyloid is released from lipid membrane by methionine oxidation.
J Biol Chem. 2003 Oct 31;278(44):42959-65. Epub 2003 Aug 18. PubMed
Sernee MF, Evin G, Culvenor JG, Villadangos JA, Beyreuther K, Masters CL, Cappai R.
Selecting cells with different Alzheimer’s disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage.
Eur J Biochem. 2003 Feb;270(3):495-506. PubMed
Nunan J, Williamson NA, Hill AF, Sernee MF, Masters CL, Small DH.
Proteasome-mediated degradation of the C-terminus of the Alzheimer’s disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
J Neurosci Res. 2003 Nov 1;74(3):378-85. PubMed
Schmechel A, Zentgraf H, Scheuermann S, Fritz G, Pipkorn R, Reed J, Beyreuther K, Bayer TA, Multhaup G.
Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies.
J Biol Chem. 2003 Sep 12;278(37):35317-24. Epub 2003 Jul 1. PubMed
Beher D, Wrigley JD, Owens AP, Shearman MS.
Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.
J Neurochem. 2002 Aug;82(3):563-75. PubMed
Runz H, Rietdorf J, Tomic I, de Bernard M, Beyreuther K, Pepperkok R, Hartmann T.
Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.
J Neurosci. 2002 Mar 1;22(5):1679-89. PubMed
Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K.
The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1365-70. Epub 2002 Jan 22. PubMed
Lutjohann D, Brzezinka A, Barth E, Abramowski D, Staufenbiel M, von Bergmann K, Beyreuther K, Multhaup G, Bayer TA.
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.
J Lipid Res. 2002 Jul;43(7):1078-85. PubMed
Wirths O, Multhaup G, Czech C, Feldmann N, Blanchard V, Tremp G, Beyreuther K, Pradier L, Bayer TA.
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.
Brain Pathol. 2002 Jul;12(3):275-86. PubMed
Xie L, Helmerhorst E, Taddei K, Plewright B, Van Bronswijk W, Martins R.
Alzheimer’s beta-amyloid peptides compete for insulin binding to the insulin receptor.
J Neurosci. 2002 May 15; 22(10):RC221. Epub 2002 May 10. PubMed
Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W.
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
J Cell Biol. 2001 Aug 20;154(4):731-40. Epub 2001 Aug 13. PubMed
Scheuermann S, Hambsch B, Hesse L, Stumm J, Schmidt C, Beher D, Bayer TA, Beyreuther K, Multhaup G.
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer’s disease.
J Biol Chem. 2001 Sep 7;276(36):33923-9. Epub 2001 Jul 3. PubMed
Fassbender K, Simons M, Bergmann C, Stroick M, Lutjohann D, Keller P, Runz H, Kuhl S, Bertsch T, von Bergmann K, Hennerici M, Beyreuther K, Hartmann T.
Simvastatin strongly reduces levels of Alzheimer’s disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5856-61. Epub 2001 Apr 10. PubMed
Hass S, Weidemann A, Utermann G, Baier G.
Intracellular apolipoprotein E affects Amyloid Precursor Protein processing and amyloid Abeta production in COS-1 cells.
Mol Genet Genomics. 2001 Jul;265(5):791-800. PubMed
Lam FC, Liu R, Lu P, Shapiro AB, Renoir JM, Sharom FJ, Reiner PB.
beta-Amyloid efflux mediated by p-glycoprotein.
J Neurochem. 2001 Feb;76(4):1121-8. PubMed
Nunan J, Shearman MS, Checler F, Cappai R, Evin G, Beyreuther K, Masters CL, Small DH.
The C-terminal fragment of the Alzheimer’s disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase.
Eur J Biochem. 2001 Oct;268(20):5329-36. PubMed
Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ.
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Nature. 2000 Jun 8;405(6787):689-94. PubMed
Petit A, Barelli H, Morain P, Checler F.
Novel proline endopeptidase inhibitors do not modify Abeta40/42 formation and degradation by human cells expressing wild-type and swedish mutated beta-amyloid precursor protein.
Br J Pharmacol. 2000 Aug;130(7):1613-7. PubMed
Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ.
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6138-43. PubMed
Lichtenthaler SF, Wang R, Grimm H, Uljon SN, Masters CL, Beyreuther K.
Mechanism of the cleavage specificity of Alzheimer’s disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3053-8. PubMed
Ancolio K, Dumanchin C, Barelli H, Warter JM, Brice A, Campion D, Frebourg T, Checler F.
Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer’s disease.
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4119-24 PubMed
Beher D, Elle C, Underwood J, Davis JB, Ward R, Karran E, Masters CL, Beyreuther K, Multhaup G.
Proteolytic fragments of Alzheimer’s disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain.
J Neurochem. 1999 Apr;72(4):1564-73. PubMed
Blasko I, Marx F, Steiner E, Hartmann T, Grubeck-Loebenstein B.
TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs.
FASEB J. 1999 Jan;13(1):63-8. PubMed
Caswell MD, Mok SS, Henry A, Cappai R, Klug G, Beyreuther K, Masters CL, Small DH.
The amyloid beta-protein precursor of Alzheimer’s disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons.
Eur J Biochem. 1999 Dec;266(2):509-16. PubMed
Cherny RA, Legg JT, McLean CA, Fairlie DP, Huang X, Atwood CS, Beyreuther K, Tanzi RE, Masters CL, Bush AI.
Aqueous dissolution of Alzheimer’s disease Abeta amyloid deposits by biometal depletion.
J Biol Chem. 1999 Aug 13;274(33):23223-8. PubMed
Qiu Z, Strickland DK, Hyman BT, Rebeck GW.
Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons.
J Neurochem. 1999 Oct;73(4):1393-8. PubMed
Culvenor JG, McLean CA, Cutt S, Campbell BC, Maher F, Jakala P, Hartmann T, Beyreuther K, Masters CL, Li QX.
Non-Abeta component of Alzheimer’s disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.
Am J Pathol. 1999 Oct;155(4):1173-81. PubMed
McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL.
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer’s disease.
Ann Neurol. 1999 Dec;46(6):860-6. PubMed
Pradier L, Carpentier N, Delalonde L, Clavel N, Bock MD, Buee L, Mercken L, Tocque B, Czech C.
Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.
Neurobiol Dis. 1999 Feb;6(1):43-55. PubMed
Weidemann A, Paliga K, Durrwang U, Reinhard FB, Schuckert O, Evin G, Masters CL.
Proteolytic processing of the Alzheimer’s disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.
J Biol Chem. 1999 Feb 26;274(9):5823-9. PubMed
Fossgreen A, Bruckner B, Czech C, Masters CL, Beyreuther K, Paro R.
Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype.
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13703-8. PubMed
Hass S, Fresser F, Kochl S, Beyreuther K, Utermann G, Baier G.
Physical interaction of ApoE with amyloid precursor protein independent of the amyloid Abeta region in vitro.
J Biol Chem. 1998 May 29;273(22):13892-7. PubMed
Mills J, Laurent Charest D, Lam F, Beyreuther K, Ida N, Pelech SL, Reiner PB.
Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway.
J Neurosci. 1997 Dec 15;17(24):9415-22. PubMed
Peraus GC, Masters CL, Beyreuther K.
Late compartments of amyloid precursor protein transport in SY5Y cells are involved in beta-amyloid secretion.
J Neurosci. 1997 Oct 15;17(20):7714-24. PubMed
Tienari PJ, Ida N, Ikonen E, Simons M, Weidemann A, Multhaup G, Masters CL, Dotti CG, Beyreuther K.
Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons.
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4125-30. PubMed
Human Tau Antibodies
Key References
Horowitz PM, Patterson KR, Guillozet-Bongaarts AL, Reynolds MR, Carroll CA, Weintraub ST, Bennett DA,
Cryns VL, Berry RW, Binder LI.
Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer’s Disease.
J. Neurosc. 2004 Sep 8; 24 (36): 7895-7902. PubMed
Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, Miller R, Berry RW, Binder LI.
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer’s disease.
PNAS 2003 Aug 19; 100 (17): 10032-10037. PubMed
Ghoshal N, Garcia-Sierra F, Wuu J, Leurgans S, Bennett DA, Berry RW, Binder LI.
Tau Conformational Changes Correspond to Impairments of Episodic Memory in Mild Cognitive Impairment and Alzheimer’s Disease.
Exper. Neurol. 2002 Jun 28; 177: 475-493. PubMed
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