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Tau Antibodies
Tau is an intracellular microtubule-associated protein (MAP) which when assembled into polymeric filaments, is the major component of neurofibrillary tangles (NFT). NFT and extracellular amyloid plaques have been demonstrated to represent the primary pathological features of AD.
Recent studies suggest that the proteolysis of human Tau protein precedes apoptotic processes in beta-Amyloid exposed neurons. Caspase cleavage of human Tau results in truncation at aspartate residue 421. Human Tau truncated at Asp421 assembles more rapidly and more extensively into polymeric filaments in vitro than wild-type human Tau (Gamblin et al., 2003)
| Cat. No. |
Name |
Reacts with |
Clone |
Applications |
Data Sheet |
Picture |
| AB-Tau12 |
Tau-12 Antibody |
human |
Tau-12 |
WB, ELISA, IHC |
|
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| AB-TauC3 |
Tau truncated at Asp421 |
human |
Tau-C3 |
WB, ELISA, IHC |
|
 |
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Key References
Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, Miller R, Berry RW, Binder LI.
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer’s disease.
PNAS 2003 Aug 19; 100 (17): 10032-10037. PubMed
Ghoshal N, Garcia-Sierra F, Wuu J, Leurgans S, Bennett DA, Berry RW, Binder LI.
Tau Conformational Changes Correspond to Impairments of Episodic Memory in Mild Cognitive Impairment and Alzheimer’s Disease.
Exper. Neurol. 2002 Jun 28; 177: 475-493. PubMed
Horowitz PM, Patterson KR, Guillozet-Bongaarts AL, Reynolds MR, Carroll CA, Weintraub ST, Bennett DA,
Cryns VL, Berry RW, Binder LI.
Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer’s Disease.
J. Neurosc. 2004 Sep 8; 24 (36): 7895-7902. PubMed
For other references regarding this product as well as our other products please see References.
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