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Amyloid beta Antibodies
Amyloid beta (Aβ) peptides correlate with the pathology of common neurodegenerative disorders such as Alzheimer’s disease (AD). Aβ1-40 is the most common form secreted from cultured cells and found in cerebro-spinal fluid (CSF). Aβ1-42 is the major component of senile plaques and considered as the most crucial factor in AD pathogenesis.
The different Aβ-peptide species result from consecutive beta- and gamma-secretase cleaveage of transmembraneous amyloid precursor preotein (APP).
| Cat. No. |
Name |
Reacts with |
Clone |
Applications |
Data sheet |
| AB02 |
Amyloid beta antibody
(N-term) |
human, guinea pig, dog, cynomolgus |
W0-2 |
WB, ELISA, IHC |
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| CB02 |
Amyloid beta antibody
(N-term), biotin conjugate |
human, guinea pig, dog, cynomolgus |
W0-2 |
WB, ELISA, IHC |
|
| CP02 |
Amyloid beta antibody
(N-term), peroxidase conjugate |
human, guinea pig, dog, cynomolgus |
W0-2 |
WB, ELISA, IHC |
|
| AB10 |
Amyloid beta x-40 antibody
(C-term) |
human, mouse, rat,
guinea pig, dog, cynomolgus |
G2-10 |
WB, ELISA, IHC |
|
| CB10 |
Amyloid beta x-40 antibody
(C-term), biotin conjugate |
human, mouse, rat,
guinea pig, dog, cynomolgus |
G2-10 |
WB, ELISA, IHC |
|
| CP10 |
Amyloid beta x-40 antibody
(C-term), peroxidase conjugate |
human, mouse, rat,
guinea pig, dog, cynomolgus |
G2-10 |
WB, ELISA, IHC |
|
| AB11 |
Amyloid beta x-42 antibody
(C-term) |
human, mouse, rat,
guinea pig, dog, cynomolgus |
G2-11 |
WB, ELISA, IHC |
|
| AB13 |
Amyloid beta x-42 antibody
(C-term) |
human, mouse, rat,
guinea pig, dog, cynomolgus |
G2-13 |
WB, ELISA, IHC |
|
| CB13 |
Amyloid beta x-42 antibody
(C-term), biotin conjugate |
human, mouse, rat,
guinea pig, dog, cynomolgus |
G2-13 |
WB, ELISA, IHC |
|
| CP13 |
Amyloid beta x-42 antibody
(C-term), peroxidase conjugate |
human, mouse, rat,
guinea pig, dog, cynomolgus |
G2-13 |
WB, ELISA, IHC |
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Evaluation of specificity and sensitivity of mAbs in Western blot detection
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The specificity and sensitivity of our monoclonal antibodies is clearly illustrated by the following Western blot taken from Ida et al, J Biol Chem. 1996
Each amount of synthetic Aβ 1-40 or 1-42 was separated by 10-20% Tris-Tricine SDS-PAGE, blotted onto nitrocellulose membrane, and stained with each antibody (see article for more details).
Source: Ida et al J Biol Chem. 1996 Sep, 13;271(37):22908-14 PubMed
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Key References
Jensen M, Hartmann T, Engvall B, Wang R, Uljon SN, Sennvik K, Naslund J, Muehlhauser F, Nordstedt C, Beyreuther K, Lannfelt L.
Quantification of Alzheimer Amyloid β Peptides Ending at residues 40 and 42 by Novel ELISA Systems
Mol Med. 2000 Apr;6(4):291-302 PubMed
Ida N, Hartmann T, Pantel J, Schroder J, Zerfass R, Forstl H, Sandbrink R, Masters CL, Beyreuther K
Analysis of Heterogenous βA4 Peptides in Human Cerebrospinal Fluid and blood by a Newly Developed Sensitive Western Blot Assay
J Biol Chem. 1996 Sep, 13;271(37):22908-14 PubMed
For other references regarding this product as well as our other products please see References.
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